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Botulinum Toxin Type A

Neuronox

A toxin studied head-to-head against the reference toxin, with a 36-month shelf life so you can plan your inventory with confidence.

Medytox's botulinum toxin type A, approved in South Korea since 2006. It is stored refrigerated or frozen, has a 36-month shelf life and has published trials against the reference toxin.

  • Approved since2006, South Korea
  • Shelf life36 months
  • Glabella20 U in 5 points
  • Onsetbegins in 1 to 2 days
View technical data
Neuronox, botulinum toxin type a
Professional injecting botulinum toxin into a patient's glabella

Relax

What you can offer in your practice

  • Upper-face expression lines

    Glabella, forehead and crow's feet, the most requested aesthetic treatment in practice.

  • Lower third and neck

    Chin, mouth corners, platysmal bands and masseter, according to your judgment and training.

  • Combined protocols

    The foundation of a harmonization with fillers and biostimulators in the same visit.

  • Scheduled maintenance

    A treatment patients come back for: a follow-up schedule that builds loyalty.

What it is and how it works

Neuronox binds to the motor nerve terminal and inhibits the release of acetylcholine. In this way it blocks neuromuscular transmission and relaxes the treated muscle. The effect is reversible: the nerve regenerates and transmission recovers.1

It is a type A toxin complex of approximately 900 kDa, Hall strain, as a lyophilized powder with human albumin and sodium chloride.2 Outside Korea it is also marketed as Meditoxin, Botulift, Siax, Acebloc and Cunox.3

Physician administering an injectable treatment with the support of a colleague

Technical data

Manufacturer
Medytox Inc., South Korea
Active ingredient
Botulinum toxin type A, Hall strain
Presentation
100 U vial, lyophilized powder
Excipients
0.5 mg of human albumin and 0.9 mg of sodium chloride per vial
Storage
2 to 8 °C, or frozen between −15 and −5 °C
Shelf life
36 months from manufacture
Diluent
Preservative-free 0.9% saline solution

Reconstitution and glabellar injection

  1. Reconstitute

    Inject the 0.9% saline solution slowly, without foaming. If the vial's vacuum does not draw in the diluent, discard it.1

  2. Dilute according to the area

    In the package insert, 50 U in 1.25 ml gives 4 U per 0.1 ml. For the 100 U vial, the same concentration is achieved with 2.5 ml. Confirm this with the insert in your box.1

  3. Inject the glabella

    20 U in total, with a 30G needle: 5 injections of 0.1 ml (4 U per point), two in each corrugator and one in the procerus. Inject at least 1 cm above the orbital rim and away from the levator palpebrae.1

  4. Respect the timing

    Use the reconstituted vial within 24 hours, refrigerated at 2–8 °C, in a single patient. Allow at least 3 months between sessions, using the lowest effective dose.1

Value for your practice

More than a product: a service line

Toxin is the gateway to aesthetic medicine: it is the treatment most patients ask for and the one they ask for again. With Neuronox you work with a toxin studied against the reference toxin and with a storage margin that lets you buy with confidence and plan your schedule.

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Botulinum toxin

Basic and advanced course to master the technique, with our team's support after the course.

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Why professionals choose it

  • Flexible storageRefrigerated or frozen, with a 36-month shelf life: more leeway to manage your inventory.13
  • Familiar formulationA ~900 kDa complex with albumin and sodium chloride, the same class of formulation as the reference toxin.2
  • Head-to-head comparisonNon-inferior to onabotulinumtoxinA in glabellar lines, crow's feet, blepharospasm and cerebral palsy, in published trials.4567
  • Documented safety profile0.49% related reactions in post-marketing pharmacovigilance for glabellar lines (812 patients, 2011–2015), with no serious events.1

Compared with its category

Attributes published by each manufacturer or by studies, with the source of each data point. Last reviewed: October 29, 2026.

AttributeNeuronoxBotoxDysportXeominDaxxify
MoleculeComplex, ~900 kDa2Complex, 900 kDa8Size not published8150 kDa, no complexing proteins9150 kDa, albumin-free10
ExcipientsHuman albumin and sodium chloride2Human albumin and sodium chloride12Human albumin and lactose11See the package insertRTP004 peptide10
Unopened vial2 to 8 °C or frozen12 to 8 °C12See the package insertUp to 25 °C920 to 25 °C or 2 to 8 °C10

Units of different botulinum toxins are not interchangeable between brands: each product has its own potency and its own dosing regimen.

Evidence and support

  • Won CH et al. Dermatologic Surgery, 2013.
    Phase III in glabellar lines, 314 patients, 20 U: 93.7% response at week 4 versus 94.5% with onabotulinumtoxinA, with no differences at weeks 8, 12 and 16. The article describes the product as a toxin of the same strain; it corresponds to Medytox's registration trial.4
  • Lim JH et al. Journal of Dermatological Treatment, 2021.
    Crow's feet, 220 patients in phase III, 24 U: 83% response with Neuronox and with onabotulinumtoxinA; non-inferior and with similar safety.5
  • Yoon JS, Kim JC, Lee SY. Korean Journal of Ophthalmology, 2009.
    Essential blepharospasm, 60 patients: non-inferior to onabotulinumtoxinA.6
  • Bang MS et al. Developmental Medicine & Child Neurology, 2010.
    Equinus foot in cerebral palsy, 119 children: non-inferior to onabotulinumtoxinA.7

Indications and safety

Indications

Approved by the Korean regulator (MFDS): moderate to severe glabellar lines in adults aged 20 to 65; moderate to severe crow's feet (approved in 2019); essential blepharospasm; equinus foot due to spasticity in cerebral palsy; upper limb spasticity after stroke.113 In Costa Rica, the indications in its sanitary registration apply.

Onset and duration of effect

In the glabella, the effect begins 1 to 2 days after injection, increases during the first week and lasts about 3 to 4 months, according to the package insert.1 Response varies from patient to patient.

Contraindications

Hypersensitivity to any of the components; neuromuscular junction disorders (myasthenia gravis, Lambert-Eaton syndrome, ALS); pregnancy and breastfeeding. Use caution with aminoglycosides, muscle relaxants, anticholinergics and other drugs that affect neuromuscular transmission.1

Adverse events

In the phase III glabellar trial, 10.9% related reactions (eyelid ptosis 3.2%). In post-marketing pharmacovigilance, 0.49% (headache 0.25%), with no serious events. Class warning: possible distant spread of toxin effect.1

Every medicine has side effects. This medicine requires a prescription. See the official package insert.

We support you with Neuronox

With your order you receive the manufacturer's technical data sheet and official instructions, plus an advisor who answers your technical and clinical questions before and after your purchase.

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Questions about Neuronox

What is Neuronox?

It is a botulinum toxin type A manufactured by Medytox Inc. in South Korea, in a 100 U vial of lyophilized powder. In Korea it is marketed as Meditoxin.

How is Neuronox stored?

Refrigerated between 2 and 8 °C or frozen between −15 and −5 °C, with a shelf life of 36 months from manufacture. Once reconstituted, it is used within 24 hours, refrigerated.

What is the Neuronox dose for glabellar lines?

According to the package insert, 20 U in 5 points of 4 U (0.1 ml each): two in each corrugator and one in the procerus.

Are Neuronox units equivalent to those of other toxins?

No. Each botulinum toxin has its own potency and its own dosing regimen; units are not interchangeable between brands.

How do I buy Neuronox in Costa Rica?

MedAesthetics sells Neuronox to physicians, dentists and clinics. Message us on WhatsApp at +(506) 6047-8333 or leave us your details in the contact form, and an advisor will confirm availability and terms.

Sources

  1. Meditoxin package insert approved by the MFDS, Korea Pharmaceutical Information Center
  2. Medytoxin (Neuronox), technical chapter
  3. Medytox, official Neuronox product page
  4. Won et al., Dermatol Surg 2013
  5. Lim et al., J Dermatolog Treat 2021
  6. Yoon et al., Korean J Ophthalmol 2009
  7. Bang et al., 2010, cited by Medytox
  8. Botulinum neurotoxin formulations, Clin Cosmet Investig Dermatol
  9. Xeomin, stability study
  10. Daxxify, prescribing information
  11. Dysport, prescribing information
  12. Botox Cosmetic, prescribing information
  13. Crow's feet approval, Daily Pharm 2019
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